Mourinho had been in charge at Spurs since November 2019, replacing Mauricio Pochettino, signing a deal until the end of the 2023 season has this week lost his job again for the third time while managing Epl clubs.
The special-one has been shown the door in north London a matter of days before Spurs are due to face Manchester City in the Carabao Cup final.
In his first campaign, Mourinho took Tottenham from 14th in the Premier League to finish sixth – securing Europa League qualification – but could not go past the last-16 stage against RB Leipzig.
However, Spurs are currently seventh in the table, five points off the Champions League places.
In a statement, Spurs said: “The club can today announce that Jose Mourinho and his coaching staff Joao Sacramento, Nuno Santos, Carlos Lalin and Giovanni Cerra have been relieved of their duties.”
Spurs chairman Daniel Levy said: “Jose and his coaching staff have been with us through some of our most challenging times as a club. Jose is a true professional who showed enormous resilience during the pandemic.
“On a personal level I have enjoyed working with him and regret that things have not worked out as we both had envisaged. He will always be welcome here and we should like to thank him and his coaching staff for their contribution.”
Spurs have also confirmed that the club’s former midfielder Ryan Mason, who is currently head of player development, will take first-team training on Monday.
With Spurs now searching for a new boss, their recruitment net is expected to be cast far and wide.